Professor James Bainbridge
THE blind and partially-sighted have been given new hope
after British scientists got the go-ahead for a trial of a
revolutionary stem cell treatment.
AMD (Age-related Macular Degeneration) is caused by
faulty Retinal Pigment Epithelial (RPE) cells, which
form a supporting carpet under the light-sensitive
rods and cones in the retina.
You can repair damaged retinas with cells derived
from human embryonic stem cells
. This involves simple surgery that soon will become
as routine as cataract operations! Surgeons inject
a small patch of new cells measuring
4x6 mm (millimeters) into the eye.
By injecting replacement RPE cells derived from stem cells
in the lab, Dr Lyndon Da Cruz of Moorfield Eye Clinic
in London hopes the operation can be reduced to a simple
45-minute procedure under local anesthetic.
The London Project to Control AMD brings together
scientists from University College London (UCL),
Moorfield Eye Hospital in London and the Univ of Sheffield.
The technique is capable of restoring vision in the
vast majority of patients with Age-related Macular Degeneration
(AMD), a leading cause of blindness among the elderly that
afflicts 14 million people in Europe.
Experts at Moorfields Eye Hospital in London
will test the therapy within weeks.
They will inject cells derived from human embryonic
inherited eye condition, Stargardt’s macular dystrophy -
which affects 1 in 10,000, causes gradual loss of central vision.
Professor James Bainbridge, who will be conducting the trials,
said: “There is real potential that people with disorders
including Stargardt disease and Age-related Macular Degeneration
(AMD) might benefit.
“The ability to regenerate retinal cells from stem cells
has been a significant advance and the opportunity
to help translate such technology into new treatments
is hugely exciting.”
AMD is Britain’s leading cause of sight loss, affecting 500,000.
STEM CELL THERAPY for
MACULAR DEGENERATION and
IMPENDING BLINDNESS
There is currently no treatment for the 90% with “dry” AMD.
All this has been made possible by a 4 million pound ($8 million)
donation from an anonymous US donor, who the project’s leaders
say had become frustrated by US curbs on stem cell work.
Embryonic stem cells are the ultimate master cells of the body,
giving rise to all tissues and organs. Their use is controversial
because many people oppose embryo destruction. Britain has
encouraged such research.
“If it hasn’t become routine in 10 years it will mean we haven’t
succeeded,” he told reporters. “It has to be something that’s
available to large numbers of people.”
Similar tests on rats have already proved highly effective.